A
Ligand-agnostic sampling
Starts from apo structures. No known cofolding ligand is required.
# ligand-agnosticSTROBE / generative conformational sampling
Generative structural biology for agriculture.
Proteins move. Most screening workflows do not.
Dawn State is developing STROBE to sample ligand-free protein conformations and prioritize candidate cryptic pockets for crop-protection and enzyme-screening workflows. It returns a reviewable ensemble of generated coordinates for downstream evaluation.
From motion to coordinates
B
3D coordinate output
Returns selected, generated open-state coordinates in PDB format—not only a pocket location or score.
# coordinate-outputC
Public benchmark validation
Across 43 literature-confirmed apo/holo pairs, 27 sites were judge-verified as captured. Candidate outputs require per-case verification and contrast testing.
# validationDesigned for agricultural discovery
- Plant metabolism
- Crop protection
- Enzyme engineering
strobe0 v1.1.0
Bring a difficult target.
Request access to the private, versioned evaluation dataset and generated structural artifacts on Hugging Face.